The First U.S. Patent for The Reversal of Aging: The Prolon Fasting Mimicking Diet

Joel Kahn

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Aug 2, 2018

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If food is medicine, can you create a food program so powerful in action that it can be patented for the reversal of aging?

The answer is a stunning YES as this milestone was achieved for the fasting mimicking diet (FMD) from L-Nutra in a patent titled “Methods and formulations promoting tissue/organ regeneration, longevity and healthspan”. This 5-day plant-based food program is the results of several decades of pioneering research by Dr. Valter Longo and his team at the University of South California. Dr. Longo is recognized as a leading expert on longevity (if not the expert) and has done copious research work in describing the basic biochemical pathways by which cells age. Now the work from his lab has been awarded a fully issued patent for the support of health in humans.

The basics of the Fasting Mimicking Diet.

The FMD program translates years of basic research in yeast and animal models to humans. The diet drops calories to 1,100 on the first day and then 760 calories/day for four more consecutive days. The nutrients are key and include plant-based whole foods like nuts, olives, teas, and soup mixes that are about 60 percent fat, 10 percent protein, and 30 percent complex carbohydrates naturally low in sugar and protein. During the five days of restricted calories, exercise and alcohol are out and coffee is limited.

What is so special about the FMD?

The science. After years of experimenting with FMD in animal models and showing its benefits on metabolism and lifespan, Dr. Longo’s team analyzed the effects in a human clinical trial that was published early in 2017. One hundred healthy subjects participated in this study; half of them followed a Prolon FMD five days a month for three months and the other half ate their usual diet. Profound differences were seen in terms of weight loss, visceral fat loss, drops in blood pressure, blood sugar, blood cholesterol, and markers of inflammation, all much more favorable in the FMD group.

Even more profound was a drop if insulin-like growth factor 1 (IGF-1) — which is a biomarker for cancer growth and aging — and an increase in stem cell production, which can lead regeneration of cells. In fact, the Prolon FMD program is marketed as a program that promotes regenerative and rejuvenating health responses. There are even provocative datasuggesting that combining this FMD with cancer chemotherapy may lead to improved success and fewer side effects.

The Patent

As quoted in the patent’s official publication, “Fasting Mimicking Diet without malnutrition is effective in protecting the brain against aging and oxidative stress.” The publication further reinforces FMD’s ability to demonstrate neuroprotective properties against neurodegenerative diseases including stroke, Parkinson’s, Huntington’s, and Alzheimer’s — and that reducing food intake can diminish cognitive dysfunction. Most importantly, the patent confirms that while conventional therapies are limited in their ability to provide a coordinated regenerative process similar to the developmental process that leads to tissue generation in the embryo, FMD’s formulations and methods can overcome these limitations — and induce the beneficial cellular effects.

The Implications

Ongoing research studies of the periodic FMD, which creates a short term ketosis from plant foods, are being conducted worldwide for many important disease states including the metabolic syndrome, diabetes, cancer, autoimmune conditions, weight management, athletic performance, and cellular rejuvenation programs. Due to the exploding popularity and recognition of FMD, Prolon represents a significant transition in the way in which clinicians can advise patients regarding weight management, wellness, and longevity.